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Protein-coding gene in the species Homo sapiens
U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene .[5] [6]
This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.[6]
Interactions [ edit ] LSM8 has been shown to interact with LSM2 .[7] [8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000128534 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044155 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro" . EMBO J . 18 (20): 5789–802. doi :10.1093/emboj/18.20.5789 . PMC 1171645 PMID 10523320 . ^ a b "Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)" .^ Lehner, Ben; Sanderson Christopher M (Jul 2004). "A protein interaction framework for human mRNA degradation" . Genome Res . 14 (7): 1315–23. doi :10.1101/gr.2122004 . ISSN 1088-9051 . PMC 442147 PMID 15231747 . ^ Lehner, Ben; Semple Jennifer I; Brown Stephanie E; Counsell Damian; Campbell R Duncan; Sanderson Christopher M (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics . 83 (1): 153–67. doi :10.1016/S0888-7543(03)00235-0 . ISSN 0888-7543 . PMID 14667819 .
Further reading [ edit ]
Khusial P, Plaag R, Zieve GW (2005). "LSm proteins form heptameric rings that bind to RNA via repeating motifs". Trends Biochem. Sci . 30 (9): 522–8. doi :10.1016/j.tibs.2005.07.006 . PMID 16051491 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence" . Genome Res . 8 (11): 1097–108. doi :10.1101/gr.8.11.1097 PMID 9847074 . Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin" . EMBO J . 18 (12): 3451–62. doi :10.1093/emboj/18.12.3451 . PMC 1171424 PMID 10369684 . Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera" . Arthritis Rheum . 46 (3): 726–34. doi :10.1002/art.10220 PMID 11920408 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology" . Science . 300 (5620): 767–72. Bibcode :2003Sci...300..767S . doi :10.1126/science.1083423 . PMC 2882961 PMID 12690205 . Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7" . Nature . 424 (6945): 157–64. Bibcode :2003Natur.424..157H . doi :10.1038/nature01782 PMID 12853948 . Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics . 83 (1): 153–67. doi :10.1016/S0888-7543(03)00235-0 . PMID 14667819 . Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation" . Genome Res . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 .
