NAB2

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NAB2
Identifiers
Aliases NAB2, MADER, NGFI-A binding protein 2
External IDs MGI: 107563 HomoloGene: 4353 GeneCards: NAB2
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for NAB2
Genomic location for NAB2
Band 12q13.3 Start 57,088,894 bp[1]
End 57,095,476 bp[1]
RNA expression pattern
PBB GE NAB2 216017 s at fs.png

PBB GE NAB2 212803 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005967
NM_001330305

NM_001122895
NM_008668

RefSeq (protein)

NP_001317234
NP_005958

NP_001116367
NP_032694

Location (UCSC) Chr 12: 57.09 – 57.1 Mb Chr 10: 127.66 – 127.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a protein that in humans is encoded by the NAB2 gene.[5][6][7]

Function[edit]

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress or activate transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[7]

Pathology[edit]

Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166886 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025402 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. PMC 231349Freely accessible. PMID 8668170. 
  6. ^ Kirsch KH, Korradi Y, Johnson JP (Jul 1996). "Mader: a novel nuclear protein over expressed in human melanomas". Oncogene. 12 (5): 963–71. PMID 8649813. 
  7. ^ a b "Entrez Gene: NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)". 
  8. ^ Kabbinavar, F. F.; Hambleton, J; Mass, R. D.; Hurwitz, H. I.; Bergsland, E; Sarkar, S (2005). "Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer". Journal of Clinical Oncology. 23 (16): 3706–12. doi:10.1200/JCO.2005.00.232. PMID 15867200. 

Further reading[edit]