NACA (gene)

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Nascent polypeptide-associated complex alpha subunit
Protein NACA PDB 3LKX.png
Rendering based on PDB 3LKX.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NACA ; HSD48; NACA1; skNAC
External IDs OMIM601234 MGI106095 HomoloGene136025 GeneCards: NACA Gene
EC number
RNA expression pattern
PBB GE NACA 200735 x at tn.png
PBB GE NACA 208635 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4666 17938
Ensembl ENSG00000196531 ENSMUSG00000061315
UniProt E9PAV3 P70670
RefSeq (mRNA) NM_001113201 NM_001113199
RefSeq (protein) NP_001106673 NP_001106670
Location (UCSC) Chr 12:
56.71 – 56.73 Mb
Chr 10:
128.04 – 128.05 Mb
PubMed search [1] [2]

Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a protein which in humans is encoded by the NACA gene.[1][2][3]


NACA prevents short recently synthesized (i.e., nascent) ribosome-associated polypeptides from inappropriate interactions with cytosolic proteins. NACA binds nascent-polypeptide domains emerging from ribosomes unless it contains a signal peptide which is fully exposed. Depletion of NACA from ribosomes carrying nascent polypeptides allows the signal recognition particle (SRP) to crosslink to polypeptides regardless of whether or not they contain signal peptides or not. In the absence of NACA, proteins lacking signal peptides can be mis-translocated into the endoplasmic reticulum.[2][4]

The NACA protein is expressed in bone during development and acts as a transcriptional coactivator in conjunction with acidic activators.[3]


NACA has been shown to interact with BTF3, FADD,[5] C-jun,[6] and 3 members of taxilin family.[7]


  1. ^ "Entrez Gene: NACA nascent-polypeptide-associated complex alpha polypeptide". 
  2. ^ a b Wiedmann B, Sakai H, Davis TA, Wiedmann M (August 1994). "A protein complex required for signal-sequence-specific sorting and translocation". Nature 370 (6489): 434–40. doi:10.1038/370434a0. PMID 8047162. 
  3. ^ a b Yotov WV, St-Arnaud R (February 1996). "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1". Mamm. Genome 7 (2): 163–4. doi:10.1007/BF03035343. PMID 8835540. 
  4. ^ Rospert S, Dubaquié Y, Gautschi M (October 2002). "Nascent-polypeptide-associated complex". Cell. Mol. Life Sci. 59 (10): 1632–9. doi:10.1007/PL00012490. PMID 12475173. 
  5. ^ Stilo R, Liguoro D, di Jeso B, Leonardi A, Vito P (April 2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41. doi:10.1016/S0006-291X(03)00487-X. PMID 12684039. 
  6. ^ Moreau A, Yotov WV, Glorieux FH, St-Arnaud R (March 1998). "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription". Mol. Cell. Biol. 18 (3): 1312–21. PMC 108844. PMID 9488446. 
  7. ^ Yoshida K, Nogami S, Satoh S, Tanaka-Nakadate S, Hiraishi H, Terano A, Shirataki H (May 2005). "Interaction of the taxilin family with the nascent polypeptide-associated complex that is involved in the transcriptional and translational processes". Genes Cells 10 (5): 465–76. doi:10.1111/j.1365-2443.2005.00848.x. PMID 15836775. 

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