NADH dehydrogenase

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NADH dehydrogenase
EC number1.6.99.3
CAS number9079-67-8
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

NADH dehydrogenase (EC, cytochrome c reductase, type 1 dehydrogenase, beta-NADH dehydrogenase dinucleotide, diaphorase, dihydrocodehydrogenase I dehydrogenase, dihydronicotinamide adenine dinucleotide dehydrogenase, diphosphopyridine diaphorase, DPNH diaphorase, NADH diaphorase, NADH hydrogenase, NADH oxidoreductase, NADH-menadione oxidoreductase, reduced diphosphopyridine nucleotide diaphorase) is an enzyme with systematic name NADH:acceptor oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

NADH + H+ + acceptor ⇌ NAD+ + reduced acceptor

NADH dehydrogenase is a flavoprotein that contains iron-sulfur centres.

NADH dehydrogenase is used in the electron transport chain for generation of ATP.

See also[edit]


  1. ^ Adachi K, Okuyama T (June 1972). "Study on the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes. I. Crystallization and properties of the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes". Biochimica et Biophysica Acta. 268 (3): 629–37. doi:10.1016/0005-2744(72)90266-5. PMID 4402556.
  2. ^ Hatefi, Y.; Ragan, C.I.; Galante, Y.M. (1985). "The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system". In Martonosi, A. (ed.). The Enzymes of Biological Membranes. 4 (2nd ed.). New York: Plenum Press. pp. 1–70.
  3. ^ Hochstein LI, Dalton BP (April 1973). "Studies of a halophilic NADH dehydrogenase. I. Purification and properties of the enzyme". Biochimica et Biophysica Acta. 302 (2): 216–28. doi:10.1016/0005-2744(73)90150-2. PMID 4144655.
  4. ^ Kaniuga Z (August 1963). "The transformation of mitochondrial NADH dehydrogenase into NADH: Cytochrome c oxidoreductase". Biochimica et Biophysica Acta. 73: 550–64. doi:10.1016/0926-6569(63)90175-5. PMID 14074130.

External links[edit]