NADPH—cytochrome-c2 reductase

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NADPH—cytochrome-c2 reductase
EC no.
CAS no.37256-32-9
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a NADPH—cytochrome-c2 reductase (EC is an enzyme that catalyzes the chemical reaction

NADPH + 2 ferricytochrome c2 NADP+ + H+ + 2 ferrocytochrome c2

Thus, the two substrates of this enzyme are NADPH and ferricytochrome c2, whereas its 3 products are NADP+, H+, and ferrocytochrome c2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a heme protein as acceptor. The systematic name of this enzyme class is NADPH:ferricytochrome-c2 oxidoreductase. Other names in common use include cytochrome c2 reductase (reduced nicotinamide adenine dinucleotide, phosphate), cytochrome c2 reductase (reduced nicotinamide adenine dinucleotide, and phosphate, NADPH). It employs one cofactor, FAD.


  • Sabo DJ, Orlando JA (1968). "Isolation, purification, and some properties of reduced nicotinamide adenine dinucleotide phosphate-cytochrome C2 reductase from Rhodopseudomonas spheroides". J. Biol. Chem. 243 (13): 3742–9. PMID 4385431.