NADPH dehydrogenase

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NADPH dehydrogenase
X-ray structure of Xenobiotic Reductase A from Pseudomonas putida. PDB entry 3l5l
EC number
CAS number 9001-68-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a NADPH dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

NADPH + H+ + acceptor NADP+ + reduced acceptor

The 3 substrates of this enzyme are NADPH, H+, and acceptor, whereas its two products are NADP+ and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADPH:acceptor oxidoreductase. Other names in common use include NADPH2 diaphorase, NADPH diaphorase, OYE, diaphorase, dihydronicotinamide adenine dinucleotide phosphate dehydrogenase, NADPH-dehydrogenase, NADPH-diaphorase, NADPH2-dehydrogenase, old yellow enzyme, reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, TPNH dehydrogenase, TPNH-diaphorase, triphosphopyridine diaphorase, triphosphopyridine nucleotide diaphorase, NADPH2 dehydrogenase, and NADPH:(acceptor) oxidoreductase. It has 2 cofactors: FAD, and FMN.


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  • Walter F. Boron; Emile L. Boulpaep (2008). Medical Physiology. 

[1] [2]

  1. ^ Davis EM, Ringer KL, McConkey Me, Croteay R (2005)Enzyme Menthol deghydrogenase. (Links to an external site.)
  2. ^ (1986). Removal of ferredoxin:NADPH+ oxidoreductase from thylakoid membranes, rebinding to depleted membranes, and identification of the binding site. Journal of Biological Chemistry.