NAIP (gene)

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NAIP
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NAIP, BIRC1, NLRB1, psiNLR family, apoptosis inhibitory protein
External IDs MGI: 1298226 HomoloGene: 136092 GeneCards: 4671
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004536
NM_022892

NM_001126182
NM_010872

RefSeq (protein)

NP_004527.2
NP_075043.1

NP_001119654.1
NP_035002.2

Location (UCSC) Chr 5: 70.97 – 71.03 Mb Chr 13: 100.14 – 100.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene.[1][2]

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]

References[edit]

  1. ^ Roy N, Mahadevan MS, McLean M, Shutler G, Yaraghi Z, Farahani R, Baird S, Besner-Johnston A, Lefebvre C, Kang X, et al. (Feb 1995). "The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy". Cell 80 (1): 167–78. doi:10.1016/0092-8674(95)90461-1. PMID 7813013. 
  2. ^ a b "Entrez Gene: NAIP NLR family, apoptosis inhibitory protein". 

Further reading[edit]

External links[edit]