NLRP8

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NLRP8
Identifiers
Aliases NLRP8, CLR19.2, NALP8, NOD16, PAN4, NLR family, pyrin domain containing 8, NLR family pyrin domain containing 8
External IDs HomoloGene: 82360 GeneCards: NLRP8
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NLRP8
Genomic location for NLRP8
Band 19q13.43 Start 55,947,832 bp[1]
End 55,988,629 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_176811
NM_001317000

n/a

RefSeq (protein)

NP_001303929
NP_789781

n/a

Location (UCSC) Chr 19: 55.95 – 55.99 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals.[3][4] It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179709 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Ponsuksili S, Brunner RM, Goldammer T, et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID 16339045. 
  4. ^ Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9: 202. doi:10.1186/1471-2148-9-202. PMC 2735741Freely accessible. PMID 19682372. 

Further reading[edit]

  • Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885. 
  • Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. 
  • Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.