NAPSA

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NAPSA
Identifiers
AliasesNAPSA, KAP, Kdap, NAP1, NAPA, SNAPA, napsin A aspartic peptidase
External IDsMGI: 109365 HomoloGene: 68418 GeneCards: NAPSA
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NAPSA
Genomic location for NAPSA
Band19q13.33Start50,358,477 bp[1]
End50,365,830 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004851

NM_008437

RefSeq (protein)

NP_004842

NP_032463

Location (UCSC)Chr 19: 50.36 – 50.37 MbChr 7: 44.57 – 44.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Napsin-A is a protein that is encoded in humans by the NAPSA gene. [5]

The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131400 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002204 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: NAPSA napsin A aspartic peptidase".

Further reading[edit]