NAT10

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N-acetyltransferase 10 (GCN5-related)
Identifiers
Symbols NAT10 ; ALP; NET43
External IDs OMIM609221 MGI2138939 HomoloGene6785 GeneCards: NAT10 Gene
EC number 2.3.1.-
RNA expression pattern
PBB GE NAT10 217884 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55226 98956
Ensembl ENSG00000135372 ENSMUSG00000027185
UniProt Q9H0A0 Q8K224
RefSeq (mRNA) NM_001144030 NM_153126
RefSeq (protein) NP_001137502 NP_694766
Location (UCSC) Chr 11:
34.11 – 34.15 Mb
Chr 2:
103.72 – 103.76 Mb
PubMed search [1] [2]

N-acetyltransferase 10 is an enzyme that in humans is encoded by the NAT10 gene.[1][2]

Model organisms[edit]

Model organisms have been used in the study of NAT10 function. A conditional knockout mouse line called Nat10tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]

References[edit]

  1. ^ Lv J, Liu H, Wang Q, Tang Z, Hou L, Zhang B (Nov 2003). "Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT". Biochemical and Biophysical Research Communications 311 (2): 506–13. doi:10.1016/j.bbrc.2003.09.235. PMID 14592445. 
  2. ^ "Entrez Gene: NAT10 N-acetyltransferase 10". 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]