NAT10

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NAT10
Identifiers
Aliases NAT10, ALP, NET43, N-acetyltransferase 10
External IDs MGI: 2138939 HomoloGene: 6785 GeneCards: NAT10
RNA expression pattern
PBB GE NAT10 217884 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144030
NM_024662

NM_153126

RefSeq (protein)

NP_001137502
NP_078938

NP_694766.1
NP_694766

Location (UCSC) Chr 11: 34.11 – 34.15 Mb Chr 2: 103.72 – 103.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

N-acetyltransferase 10 is an enzyme that in humans is encoded by the NAT10 gene.[3][4]

Model organisms[edit]

Model organisms have been used in the study of NAT10 function. A conditional knockout mouse line called Nat10tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lv J, Liu H, Wang Q, Tang Z, Hou L, Zhang B (Nov 2003). "Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT". Biochemical and Biophysical Research Communications. 311 (2): 506–13. doi:10.1016/j.bbrc.2003.09.235. PMID 14592445. 
  4. ^ "Entrez Gene: NAT10 N-acetyltransferase 10". 
  5. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  6. ^ a b "International Mouse Phenotyping Consortium". 
  7. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750. 
  8. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  9. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  10. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207Freely accessible. PMID 23870131. 
  11. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]