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Available structures
PDB Human UniProt search: PDBe RCSB
Aliases NCOA4, ARA70, ELE1, PTC3, RFG, nuclear receptor coactivator 4
External IDs MGI: 1350932 HomoloGene: 38052 GeneCards: NCOA4
RNA expression pattern
PBB GE NCOA4 210774 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 46.01 – 46.03 Mb Chr 14: 32.16 – 32.18 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[3][4][5]


NCOA4 has been shown to interact with:

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (Feb 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene. 9 (2): 509–16. PMID 8290261. 
  4. ^ a b Yeh S, Chang C (May 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5517–21. PMC 39278Freely accessible. PMID 8643607. doi:10.1073/pnas.93.11.5517. 
  5. ^ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4". 
  6. ^ Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (Jan 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Molecular Endocrinology. 13 (1): 117–28. PMID 9892017. doi:10.1210/mend.13.1.0214. 
  7. ^ Miyamoto H, Yeh S, Wilding G, Chang C (Jun 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (13): 7379–84. PMC 22623Freely accessible. PMID 9636157. doi:10.1073/pnas.95.13.7379. 
  8. ^ Lin HK, Yeh S, Kang HY, Chang C (Jun 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7200–5. PMC 34646Freely accessible. PMID 11404460. doi:10.1073/pnas.121173298. 
  9. ^ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (10): 5458–63. PMC 21881Freely accessible. PMID 10318905. doi:10.1073/pnas.96.10.5458. 
  10. ^ Zhou ZX, He B, Hall SH, Wilson EM, French FS (Feb 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Molecular Endocrinology. 16 (2): 287–300. PMID 11818501. doi:10.1210/mend.16.2.0765. 
  11. ^ He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry. 277 (12): 10226–35. PMID 11779876. doi:10.1074/jbc.M111975200. 
  12. ^ Gao T, Brantley K, Bolu E, McPhaul MJ (Oct 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Molecular Endocrinology. 13 (10): 1645–56. PMID 10517667. doi:10.1210/mend.13.10.0352. 
  13. ^ He B, Wilson EM (Mar 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Molecular and Cellular Biology. 23 (6): 2135–50. PMC 149467Freely accessible. PMID 12612084. doi:10.1128/mcb.23.6.2135-2150.2003. 
  14. ^ Heinlein CA, Ting HJ, Yeh S, Chang C (Jun 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry. 274 (23): 16147–52. PMID 10347167. doi:10.1074/jbc.274.23.16147. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.