NCOA4

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NCOA4
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases NCOA4, ARA70, ELE1, PTC3, RFG, nuclear receptor coactivator 4
External IDs MGI: 1350932 HomoloGene: 38052 GeneCards: 8031
RNA expression pattern
PBB GE NCOA4 210774 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005437
NM_001145260
NM_001145261
NM_001145262
NM_001145263

NM_001033988
NM_001284319
NM_019744

RefSeq (protein)

NP_001138732.1
NP_001138733.1
NP_001138734.1
NP_001138735.1
NP_005428.1

n/a

Location (UCSC) Chr 10: 46.01 – 46.03 Mb Chr 14: 32.16 – 32.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[1][2][3]

Interactions[edit]

NCOA4 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (Feb 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene 9 (2): 509–16. PMID 8290261. 
  2. ^ a b Yeh S, Chang C (May 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proceedings of the National Academy of Sciences of the United States of America 93 (11): 5517–21. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607. 
  3. ^ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4". 
  4. ^ Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (Jan 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Molecular Endocrinology 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017. 
  5. ^ Miyamoto H, Yeh S, Wilding G, Chang C (Jun 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States of America 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157. 
  6. ^ Lin HK, Yeh S, Kang HY, Chang C (Jun 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proceedings of the National Academy of Sciences of the United States of America 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460. 
  7. ^ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National Academy of Sciences of the United States of America 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905. 
  8. ^ Zhou ZX, He B, Hall SH, Wilson EM, French FS (Feb 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Molecular Endocrinology 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501. 
  9. ^ He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876. 
  10. ^ Gao T, Brantley K, Bolu E, McPhaul MJ (Oct 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Molecular Endocrinology 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667. 
  11. ^ He B, Wilson EM (Mar 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Molecular and Cellular Biology 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084. 
  12. ^ Heinlein CA, Ting HJ, Yeh S, Chang C (Jun 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.