NDC80

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NDC80
Protein NDC80 PDB 2igp.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NDC80, HEC, HEC1, HsHec1, KNTC2, TID3, hskinetochore complex component
External IDs MGI: 1914302 HomoloGene: 38141 GeneCards: NDC80
RNA expression pattern
PBB GE NDC80 204162 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006101

NM_023294

RefSeq (protein)

NP_006092

NP_075783.2
NP_075783

Location (UCSC) Chr 18: 2.57 – 2.62 Mb Chr 17: 71.5 – 71.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.[3][4][5]

Function[edit]

HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[supplied by OMIM][5]

Interactions[edit]

NDC80 has been shown to interact with MIS12,[6][7] NEK2[8][9] and PSMC2.[9]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Chen Y, Riley DJ, Chen PL, Lee WH (Oct 1997). "HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis". Molecular and Cellular Biology. 17 (10): 6049–56. doi:10.1128/mcb.17.10.6049. PMC 232454Freely accessible. PMID 9315664. 
  4. ^ Martin-Lluesma S, Stucke VM, Nigg EA (Sep 2002). "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2". Science. 297 (5590): 2267–70. doi:10.1126/science.1075596. PMID 12351790. 
  5. ^ a b "Entrez Gene: NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae)". 
  6. ^ Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519Freely accessible. PMID 15371340. 
  7. ^ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. 
  8. ^ Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH (Dec 2002). "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation". The Journal of Biological Chemistry. 277 (51): 49408–16. doi:10.1074/jbc.M207069200. PMID 12386167. 
  9. ^ a b Chen Y, Sharp ZD, Lee WH (Sep 1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". The Journal of Biological Chemistry. 272 (38): 24081–7. doi:10.1074/jbc.272.38.24081. PMID 9295362. 

Further reading[edit]