NDEL1

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NDEL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNDEL1, EOPA, MITAP1, NDE1L1, NDE2, NUDEL, nudE neurodevelopment protein 1 like 1
External IDsOMIM: 607538 MGI: 1932915 HomoloGene: 32567 GeneCards: NDEL1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NDEL1
Genomic location for NDEL1
Band17p13.1Start8,413,131 bp[1]
End8,490,411 bp[1]
RNA expression pattern
PBB GE NDEL1 208093 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001025579
NM_030808
NM_001330129

NM_023668
NM_001363304
NM_001363305

RefSeq (protein)

NP_001020750
NP_001317058
NP_110435

NP_076157
NP_001350233
NP_001350234

Location (UCSC)Chr 17: 8.41 – 8.49 MbChr 11: 68.82 – 68.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.[5][6][7]

This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

Interactions[edit]

NDEL1 has been shown to interact with Cyclin-dependent kinase 5,[5] YWHAE,[8] PAFAH1B1[5][8] and DISC1.[9][10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166579 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018736 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b c Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH (Dec 2000). "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron. 28 (3): 697–711. doi:10.1016/S0896-6273(00)00147-1. PMID 11163260.
  6. ^ Sasaki S, Shionoya A, Ishida M, Gambello MJ, Yingling J, Wynshaw-Boris A, Hirotsune S (Dec 2000). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system". Neuron. 28 (3): 681–96. doi:10.1016/S0896-6273(00)00146-X. PMID 11163259.
  7. ^ a b "Entrez Gene: NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1".
  8. ^ a b Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A (Jul 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nature Genetics. 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778.
  9. ^ Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Human Molecular Genetics. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
  10. ^ Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A (Jan 2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proceedings of the National Academy of Sciences of the United States of America. 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMC 140954. PMID 12506198.

Further reading[edit]