NDRG1

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NDRG1
Identifiers
Aliases NDRG1, CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5, N-myc downstream regulated 1
External IDs MGI: 1341799 HomoloGene: 55953 GeneCards: NDRG1
Genetically Related Diseases
post-traumatic stress disorder[1]
RNA expression pattern
PBB GE NDRG1 200632 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135242
NM_001258432
NM_001258433
NM_006096

NM_008681

RefSeq (protein)

NP_001128714
NP_001245361
NP_001245362
NP_006087

NP_032707.2
NP_032707

Location (UCSC) Chr 8: 133.24 – 133.3 Mb Chr 15: 66.93 – 66.97 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.[4][5][6][7]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation[citation needed]. Mutations in this gene have been reported to be causative the autosomal-recessive version of Charcot-Marie-Tooth disease known as CMT4D.[7] It has been reported that NDRG1 localizes to the endosomes and is a Rab4a effector involved in vesicular recycling.[8]

References[edit]

  1. ^ "Diseases that are genetically associated with NDRG1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ van Belzen N, Dinjens WN, Diesveld MP, Groen NA, van der Made AC, Nozawa Y, Vlietstra R, Trapman J, Bosman FT (Sep 1997). "A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms". Lab Invest. 77 (1): 85–92. PMID 9251681. 
  5. ^ Kokame K, Kato H, Miyata T (Jan 1997). "Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes". J Biol Chem. 271 (47): 29659–65. doi:10.1074/jbc.271.47.29659. PMID 8939898. 
  6. ^ Zhang J, Chen S, Zhang W, Zhang J, Liu X, Shi H, Che H, Wang W, Li F, Yao L (Jun 2008). "Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region". Gene. 417 (1-2): 5–12. doi:10.1016/j.gene.2008.03.002. PMID 18455888. 
  7. ^ a b "Entrez Gene: NDRG1 N-myc downstream regulated gene 1". 
  8. ^ Kachhap SK, Faith D, Qian DZ, et al. (2007). Heisenberg C, ed. "The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin". PLoS ONE. 2 (9): e844. doi:10.1371/journal.pone.0000844. PMC 1952073Freely accessible. PMID 17786215.  open access publication – free to read

Further reading[edit]

External links[edit]