NEDD1

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NEDD1
Identifiers
Aliases NEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1
External IDs MGI: 97293 HomoloGene: 7439 GeneCards: NEDD1
RNA expression pattern
PBB GE NEDD1 gnf1h02669 s at fs.png

PBB GE NEDD1 gnf1h02668 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135175
NM_001135176
NM_001135177
NM_152905

NM_008682

RefSeq (protein)

NP_001128647
NP_001128648
NP_001128649
NP_690869

NP_032708.2
NP_032708

Location (UCSC) Chr 12: 96.91 – 96.95 Mb Chr 10: 92.68 – 92.72 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene [3] and encodes the protein NEDD1.

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.


References[edit]

Further reading[edit]