Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.
NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.
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Sdelci S, Schütz M, Pinyol R, et al. (2012). "Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.". Curr Biol. 22 (16): 1516–23. doi:10.1016/j.cub.2012.06.027. PMID22818914.
Takai S, Yoshida Y, Noda M, et al. (1995). "Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization.". Hum. Genet. 95 (1): 96–8. doi:10.1007/BF00225082. PMID7814034.