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Neurofilament, medium polypeptide
Symbols NEFM ; NEF3; NF-M; NFM
External IDs OMIM162250 MGI97314 HomoloGene38041 GeneCards: NEFM Gene
RNA expression pattern
PBB GE NEFM 205113 at tn.png
More reference expression data
Species Human Mouse
Entrez 4741 18040
Ensembl ENSG00000104722 ENSMUSG00000022054
UniProt P07197 P08553
RefSeq (mRNA) NM_001105541 NM_008691
RefSeq (protein) NP_001099011 NP_032717
Location (UCSC) Chr 8:
24.91 – 24.92 Mb
Chr 14:
68.08 – 68.12 Mb
PubMed search [1] [2]

Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.[1][2]


Neurofilaments are type IV intermediate filament heteropolymers composed of light (NEFL), medium (this protein), and heavy (NEFH) chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage.[2]


Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.