NEFM

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NEFM
Identifiers
Aliases NEFM, NEF3, NF-M, NFM, neurofilament, medium polypeptide
External IDs HomoloGene: 38041 GeneCards: 4741
RNA expression pattern
PBB GE NEFM 205113 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005382
NM_001105541

n/a

RefSeq (protein)

NP_005373.2

n/a

Location (UCSC) Chr 8: 24.91 – 24.92 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.[1][2]

Function[edit]

Neurofilaments are type IV intermediate filament heteropolymers composed of light (NEFL), medium (this protein), and heavy (NEFH) chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage.[2]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.