NEIL2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NEIL2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NEIL2, NEH2, NEI2, nei like DNA glycosylase 2
External IDs MGI: 2686058 HomoloGene: 17032 GeneCards: NEIL2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135746
NM_001135747
NM_001135748
NM_145043

NM_201610

RefSeq (protein)

NP_963904.2
NP_963904

Location (UCSC) Chr 8: 11.77 – 11.79 Mb Chr 14: 63.18 – 63.19 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene.[3][4][5]

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hazra TK, Kow YW, Hatahet Z, Imhoff B, Boldogh I, Mokkapati SK, Mitra S, Izumi T (Aug 2002). "Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions". J Biol Chem. 277 (34): 30417–20. doi:10.1074/jbc.C200355200. PMID 12097317. 
  4. ^ Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK (Sep 2007). "Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress". J Biol Chem. 282 (39): 28474–84. doi:10.1074/jbc.M704672200. PMC 2679419Freely accessible. PMID 17686777. 
  5. ^ a b "Entrez Gene: NEIL2 nei like 2 (E. coli)". 

Further reading[edit]