NEK2

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NEK2
Protein NEK2 PDB 2jav.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NEK2, HsPK21, NEK2A, NLK1, PPP1R111, RP67, NIMA related kinase 2
External IDs MGI: 109359 HomoloGene: 74441 GeneCards: NEK2
RNA expression pattern
PBB GE NEK2 211080 s at fs.png

PBB GE NEK2 204641 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204182
NM_001204183
NM_002497

NM_010892

RefSeq (protein)

NP_001191111
NP_001191112
NP_002488

NP_035022.2
NP_035022

Location (UCSC) Chr 1: 211.66 – 211.68 Mb Chr 1: 191.82 – 191.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene.[3][4]

Interactions[edit]

NEK2 has been shown to interact with MAPK1[5] and NDC80.[6][7] Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not [Uniprot].

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Schultz SJ, Nigg EA (Feb 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451. 
  4. ^ "Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2". 
  5. ^ Lou Y, Xie W, Zhang DF, Yao JH, Luo ZF, Wang YZ, Shi YY, Yao XB (Aug 2004). "Nek2A specifies the centrosomal localization of Erk2". Biochem. Biophys. Res. Commun. 321 (2): 495–501. doi:10.1016/j.bbrc.2004.06.171. PMID 15358203. 
  6. ^ Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH (Dec 2002). "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation". J. Biol. Chem. 277 (51): 49408–16. doi:10.1074/jbc.M207069200. PMID 12386167. 
  7. ^ Chen Y, Sharp ZD, Lee WH (Sep 1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". J. Biol. Chem. 272 (38): 24081–7. doi:10.1074/jbc.272.38.24081. PMID 9295362. 

Further reading[edit]