NEK6

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NEK6
Identifiers
AliasesNEK6, SID6-1512, NIMA related kinase 6
External IDsMGI: 1891638 HomoloGene: 49379 GeneCards: NEK6
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for NEK6
Genomic location for NEK6
Band9q33.3Start124,257,606 bp[1]
End124,353,307 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001159631
NM_021606

RefSeq (protein)

NP_001153103
NP_067619

Location (UCSC)Chr 9: 124.26 – 124.35 MbChr 2: 38.51 – 38.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.[5][6]

Function[edit]

The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[6]

It is a protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.[7]

Interactions[edit]

NEK6 has been shown to interact with NEK9.[8][9][10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119408 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026749 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Li MZ, Yu L, Liu Q, Chu JY, Zhao SY (April 2000). "Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3→q34.11 by radiation hybrid mapping". Cytogenet Cell Genet. 87 (3–4): 271–2. doi:10.1159/000015445. PMID 10702691.
  6. ^ a b "Entrez Gene: NEK6 NIMA (never in mitosis gene a)-related kinase 6".
  7. ^ Q9HC98
  8. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. ^ Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J (September 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". J. Biol. Chem. 278 (37): 34897–909. doi:10.1074/jbc.M303663200. PMID 12840024.
  10. ^ Roig J, Mikhailov A, Belham C, Avruch J (July 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC 186374. PMID 12101123.

Further reading[edit]