NEK8

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NEK8
Identifiers
Aliases NEK8, JCK, NEK12A, NPHP9, RHPD2, NIMA related kinase 8
External IDs MGI: 1890646 HomoloGene: 84442 GeneCards: NEK8
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178170

NM_080849

RefSeq (protein)

NP_835464

NP_543125.1
NP_543125

Location (UCSC) Chr 17: 28.73 – 28.74 Mb Chr 11: 78.17 – 78.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase Nek8, also known as never in mitosis A-related kinase 8, is an enzyme that in humans is encoded by the NEK8 gene.[3][4]

Function[edit]

Nek8 is a member of the serine/threonine-specific protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase.[3]

Clinical significance[edit]

Mutations in the NEK8 gene associated with nephronophthisis.[5][6]

References[edit]

Further reading[edit]