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Sialidase 2 (cytosolic sialidase)
Protein NEU2 PDB 1snt.png
PDB rendering based on 1snt.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NEU2 ; SIAL2
External IDs OMIM605528 MGI1344417 HomoloGene3927 ChEMBL: 3200 GeneCards: NEU2 Gene
EC number
RNA expression pattern
PBB GE NEU2 221368 at tn.png
More reference expression data
Species Human Mouse
Entrez 4759 23956
Ensembl ENSG00000115488 ENSMUSG00000079434
UniProt Q9Y3R4 Q9JMH3
RefSeq (mRNA) NM_005383.2 NM_001160163.1
RefSeq (protein) NP_005374.2 NP_001153635.1
Location (UCSC) Chr 2:
233.9 – 233.9 Mb
Chr 1:
89.41 – 89.49 Mb
PubMed search [1] [2]

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.[1][2][3]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.[3]


  1. ^ Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics 57 (1): 137–143. doi:10.1006/geno.1999.5749. PMID 10191093. 
  2. ^ Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem 279 (5): 3169–3179. doi:10.1074/jbc.M308381200. PMID 14613940. 
  3. ^ a b "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)". 

Further reading[edit]