NEU2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NEU2
Protein NEU2 PDB 1snt.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NEU2, SIAL2, neuraminidase 2 (cytosolic sialidase)
External IDs MGI: 1344417 HomoloGene: 3927 GeneCards: 4759
RNA expression pattern
PBB GE NEU2 221368 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005383

NM_001160163
NM_001160164
NM_001160165
NM_015750

RefSeq (protein)

NP_005374.2

NP_001153635.1
NP_001153636.1
NP_001153637.1
NP_056565.1

Location (UCSC) Chr 2: 233.03 – 233.04 Mb Chr 1: 87.51 – 87.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.[1][2][3]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.[3]

References[edit]

  1. ^ Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics 57 (1): 137–143. doi:10.1006/geno.1999.5749. PMID 10191093. 
  2. ^ Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem 279 (5): 3169–3179. doi:10.1074/jbc.M308381200. PMID 14613940. 
  3. ^ a b "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)". 

Further reading[edit]