NEU2

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NEU2
Protein NEU2 PDB 1snt.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NEU2, SIAL2, neuraminidase 2 (cytosolic sialidase), neuraminidase 2
External IDs MGI: 1344417 HomoloGene: 3927 GeneCards: NEU2
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for NEU2
Genomic location for NEU2
Band 2q37.1 Start 233,032,672 bp[1]
End 233,035,057 bp[1]
RNA expression pattern
PBB GE NEU2 221368 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005383

NM_001160163
NM_001160164
NM_001160165
NM_015750

RefSeq (protein)

NP_005374

NP_001153635
NP_001153636
NP_001153637
NP_056565

Location (UCSC) Chr 2: 233.03 – 233.04 Mb Chr 2: 87.51 – 87.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.[5][6][7]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115488 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079434 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics. 57 (1): 137–143. PMID 10191093. doi:10.1006/geno.1999.5749. 
  6. ^ Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem. 279 (5): 3169–3179. PMID 14613940. doi:10.1074/jbc.M308381200. 
  7. ^ a b "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)". 

Further reading[edit]