NEU3

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NEU3
Identifiers
Aliases NEU3, SIAL3, neuraminidase 3 (membrane sialidase), neuraminidase 3, membrane sialidase, neuraminidase 3
External IDs MGI: 1355305 HomoloGene: 4847 GeneCards: NEU3
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NEU3
Genomic location for NEU3
Band 11q13.4 Start 74,988,134 bp[1]
End 75,018,893 bp[1]
RNA expression pattern
PBB GE NEU3 206948 at fs.png

PBB GE NEU3 216083 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006656

NM_016720

RefSeq (protein)

NP_006647

NP_057929

Location (UCSC) Chr 11: 74.99 – 75.02 Mb Chr 11: 99.81 – 99.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.[5][6]

Function[edit]

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.[6]

Interactions[edit]

NEU3 has been shown to interact with Grb2.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162139 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035239 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun. 261 (1): 21–7. PMID 10405317. doi:10.1006/bbrc.1999.0973. 
  6. ^ a b "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)". 
  7. ^ Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T (Jul 2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. PMID 12730204. doi:10.1074/jbc.M212200200. 

Further reading[edit]