From Wikipedia, the free encyclopedia
Jump to: navigation, search
Sialidase 3 (membrane sialidase)
Symbols NEU3 ; SIAL3
External IDs OMIM604617 MGI1355305 HomoloGene4847 ChEMBL: 3046 GeneCards: NEU3 Gene
EC number
RNA expression pattern
PBB GE NEU3 216083 s at tn.png
PBB GE NEU3 206948 at tn.png
More reference expression data
Species Human Mouse
Entrez 10825 50877
Ensembl ENSG00000162139 ENSMUSG00000035239
UniProt Q9UQ49 Q9JMH7
RefSeq (mRNA) NM_006656.5 NM_016720.2
RefSeq (protein) NP_006647.3 NP_057929.1
Location (UCSC) Chr 11:
74.7 – 74.73 Mb
Chr 7:
106.96 – 106.98 Mb
PubMed search [1] [2]

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.[1][2]


This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.[2]


NEU3 has been shown to interact with Grb2.[3]


  1. ^ Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun 261 (1): 21–7. doi:10.1006/bbrc.1999.0973. PMID 10405317. 
  2. ^ a b "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)". 
  3. ^ Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T (Jul 2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. doi:10.1074/jbc.M212200200. PMID 12730204. 

Further reading[edit]