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Neuronal differentiation 2
Symbols NEUROD2 ; NDRF; bHLHa1
External IDs OMIM601725 MGI107755 HomoloGene4489 GeneCards: NEUROD2 Gene
RNA expression pattern
PBB GE NEUROD2 210271 at tn.png
More reference expression data
Species Human Mouse
Entrez 4761 18013
Ensembl ENSG00000171532 ENSMUSG00000038255
UniProt Q15784 Q62414
RefSeq (mRNA) NM_006160 NM_010895
RefSeq (protein) NP_006151 NP_035025
Location (UCSC) Chr 17:
39.6 – 39.61 Mb
Chr 11:
98.33 – 98.33 Mb
PubMed search [1] [2]

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[1][2]


This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[2]


NEUROD2 has been shown to interact with Protein kinase N1.[3]


  1. ^ Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405. 
  2. ^ a b "Entrez Gene: NEUROD2 neurogenic differentiation 2". 
  3. ^ Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular Brain Research 74 (1-2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.