The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.
^Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID7749981.
Jabado N, Le Deist F, Fisher A, Hivroz C (Nov 1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology24 (11): 2646–52. doi:10.1002/eji.1830241112. PMID7957556.
Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A (Nov 1994). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID7999066.
Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT (Sep 1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology26 (9): 2181–8. doi:10.1002/eji.1830260933. PMID8814265.
Chow CW, Rincón M, Cavanagh J, Dickens M, Davis RJ (Nov 1997). "Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway". Science278 (5343): 1638–41. doi:10.1126/science.278.5343.1638. PMID9374467.
Amasaki Y, Masuda ES, Imamura R, Arai K, Arai N (Mar 1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets". Journal of Immunology160 (5): 2324–33. PMID9498773.
Zhu J, Shibasaki F, Price R, Guillemot JC, Yano T, Dötsch V, Wagner G, Ferrara P, McKeon F (May 1998). "Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1". Cell93 (5): 851–61. doi:10.1016/S0092-8674(00)81445-2. PMID9630228.
Aramburu J, Garcia-Cózar F, Raghavan A, Okamura H, Rao A, Hogan PG (Apr 1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Molecular Cell1 (5): 627–37. doi:10.1016/S1097-2765(00)80063-5. PMID9660947.
Imamura R, Masuda ES, Naito Y, Imai S, Fujino T, Takano T, Arai K, Arai N (Oct 1998). "Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells". Journal of Immunology161 (7): 3455–63. PMID9759864.
Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID10493829.
Amasaki Y, Adachi S, Ishida Y, Iwata M, Arai N, Arai K, Miyatake S (Jul 2002). "A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells". The Journal of Biological Chemistry277 (28): 25640–8. doi:10.1074/jbc.M201860200. PMID11997392.