NFATC3

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NFATC3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NFATC3, NFAT4, NFATX, nuclear factor of activated T-cells 3
External IDs MGI: 103296 HomoloGene: 27827 GeneCards: 4775
RNA expression pattern
PBB GE NFATC3 207416 s at tn.png

PBB GE NFATC3 210555 s at tn.png

PBB GE NFATC3 210556 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173165
NM_004555
NM_173163
NM_173164

NM_010901

RefSeq (protein)

NP_004546.1
NP_775186.1
NP_775188.1
NP_004546.1
NP_775188.1

n/a

Location (UCSC) Chr 16: 68.08 – 68.23 Mb Chr 8: 106.06 – 106.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.[3][4]

Function[edit]

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981. 
  4. ^ a b "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.