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Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NFATC4 ; NF-AT3; NF-ATC4; NFAT3
External IDs OMIM602699 MGI1920431 HomoloGene3349 GeneCards: NFATC4 Gene
RNA expression pattern
PBB GE NFATC4 213345 at tn.png
PBB GE NFATC4 205897 at tn.png
More reference expression data
Species Human Mouse
Entrez 4776 73181
Ensembl ENSG00000100968 ENSMUSG00000023411
UniProt Q14934 Q8K120
RefSeq (mRNA) NM_001136022 NM_001168346
RefSeq (protein) NP_001129494 NP_001161818
Location (UCSC) Chr 14:
24.37 – 24.38 Mb
Chr 14:
55.82 – 55.83 Mb
PubMed search [1] [2]

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.[1][2]


The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.[2]

NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. Indeed NFAT3 (NFATc4) is an inhibitor of cell motility by blocking the expression of LCN2.[3]


NFATC4 has been shown to interact with CREB-binding protein.[4]

See also[edit]


  1. ^ Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981. 
  2. ^ a b "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4". 
  3. ^ Fougère M, Gaudineau B, Barbier J, Guaddachi F, Feugeas JP, Auboeuf D, Jauliac S (Apr 2010). "NFAT3 transcription factor inhibits breast cancer cell motility by targeting the Lipocalin 2 gene". Oncogene 29 (15): 2292–301. doi:10.1038/onc.2009.499. PMID 20101218. 
  4. ^ Yang T, Davis RJ, Chow CW (Oct 2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation". The Journal of Biological Chemistry 276 (43): 39569–76. doi:10.1074/jbc.M102961200. PMID 11514544. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.