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Nuclear factor, erythroid 2
Protein NFE2 PDB 1LVX.png
Rendering based on PDB 1LVX.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NFE2 ; NF-E2; p45
External IDs OMIM601490 MGI97308 HomoloGene4491 GeneCards: NFE2 Gene
RNA expression pattern
PBB GE NFE2 209930 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4778 18022
Ensembl ENSG00000123405 ENSMUSG00000058794
UniProt Q16621 Q07279
RefSeq (mRNA) NM_001136023 NM_001302338
RefSeq (protein) NP_001129495 NP_001289267
Location (UCSC) Chr 12:
54.29 – 54.3 Mb
Chr 15:
103.25 – 103.26 Mb
PubMed search [1] [2]

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.[1][2]


NFE2 has been shown to interact with CREB-binding protein.[3]


  1. ^ Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S et al. (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol 13 (9): 5604–12. PMC 360284. PMID 8355703. 
  2. ^ "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa". 
  3. ^ Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.