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Nuclear factor, erythroid 2-like 1
Symbols NFE2L1 ; LCR-F1; NRF1; TCF11
External IDs OMIM163260 MGI99421 HomoloGene20685 GeneCards: NFE2L1 Gene
RNA expression pattern
PBB GE NFE2L1 214179 s at tn.png
PBB GE NFE2L1 200758 s at tn.png
PBB GE NFE2L1 200759 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4779 18023
Ensembl ENSG00000082641 ENSMUSG00000038615
UniProt Q14494 Q61985
RefSeq (mRNA) NM_003204 NM_001130450
RefSeq (protein) NP_003195 NP_001123922
Location (UCSC) Chr 17:
48.05 – 48.06 Mb
Chr 11:
96.82 – 96.83 Mb
PubMed search [1] [2]

Nuclear factor erythroid 2-related factor 1 is a protein that in humans is encoded by the NFE2L1 gene.[1][2][3]


NFE2L1 has been shown to interact with C-jun.[4]


  1. ^ Chan JY, Han XL, Kan YW (Dec 1993). "Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast". Proceedings of the National Academy of Sciences of the United States of America 90 (23): 11371–5. doi:10.1073/pnas.90.23.11371. PMC 47984. PMID 8248256. 
  2. ^ Chan JY, Kwong M, Lu R, Chang J, Wang B, Yen TS, Kan YW (Mar 1998). "Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice". The EMBO Journal 17 (6): 1779–87. doi:10.1093/emboj/17.6.1779. PMC 1170525. PMID 9501099. 
  3. ^ "Entrez Gene: NFE2L1 nuclear factor (erythroid-derived 2)-like 1". 
  4. ^ Venugopal R, Jaiswal AK (Dec 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.