NFIL3

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NFIL3
Identifiers
AliasesNFIL3, E4BP4, IL3BP1, NF-IL3A, NFIL3A, nuclear factor, interleukin 3 regulated
External IDsMGI: 109495 HomoloGene: 3928 GeneCards: NFIL3
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for NFIL3
Genomic location for NFIL3
Band9q22.31Start91,409,045 bp[1]
End91,423,862 bp[1]
RNA expression pattern
PBB GE NFIL3 203574 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005384
NM_001289999
NM_001290000

NM_017373

RefSeq (protein)

NP_001276928
NP_001276929
NP_005375

NP_059069

Location (UCSC)Chr 9: 91.41 – 91.42 MbChr 13: 52.97 – 52.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.[5]

Function[edit]

Expression of interleukin-3 (IL3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.[5][6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165030 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056749 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated".
  6. ^ Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology. 15 (11): 6055–63. PMC 230857. PMID 7565758.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.