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Nuclear factor I/X (CCAAT-binding transcription factor)
External IDs OMIM164005 MGI97311 HomoloGene1872 GeneCards: NFIX Gene
RNA expression pattern
PBB GE NFIX 209807 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4784 18032
Ensembl ENSG00000008441 ENSMUSG00000001911
UniProt Q14938 P70257
RefSeq (mRNA) NM_001271043 NM_001081981
RefSeq (protein) NP_001257972 NP_001075450
Location (UCSC) Chr 19:
13 – 13.1 Mb
Chr 8:
84.7 – 84.8 Mb
PubMed search [1] [2]

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene.[1][2][3] NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.[4]


NFIX has been shown to interact with SKI protein[5] and it is also known to interact with AP-1.[4] NFI-X3 has been shown to interact with STAT3.[4]


  1. ^ Seisenberger C, Winnacker EL, Scherthan H (Aug 1993). "Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH". Hum Genet 91 (6): 535–7. doi:10.1007/bf00205076. PMID 8340106. 
  2. ^ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749. 
  3. ^ "Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)". 
  4. ^ a b c Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, Kordula T (November 2011). "A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40". J. Biol. Chem. 286 (46): 39893–903. doi:10.1074/jbc.M111.257451. PMC 3220556. PMID 21953450. 
  5. ^ Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (October 1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.