NFKBIB

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
NFKBIB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNFKBIB, IKBB, TRIP9, NFKB inhibitor beta
External IDsOMIM: 604495 MGI: 104752 HomoloGene: 37631 GeneCards: NFKBIB
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NFKBIB
Genomic location for NFKBIB
Band19q13.2Start38,899,700 bp[1]
End38,908,893 bp[1]
RNA expression pattern
PBB GE NFKBIB 214062 x at fs.png

PBB GE NFKBIB 214448 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001716
NM_001243116
NM_002503
NM_001369699
NM_001369700

NM_010908
NM_001306222

RefSeq (protein)

NP_001230045
NP_002494
NP_001356628
NP_001356629

NP_001293151
NP_035038

Location (UCSC)Chr 19: 38.9 – 38.91 MbChr 7: 28.76 – 28.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene.[5]

Function[edit]

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM][6]

Interactions[edit]

NFKBIB has been shown to interact with:

References[edit]

  1. ^ a b c ENSG00000282905 GRCh38: Ensembl release 89: ENSG00000104825, ENSG00000282905 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030595 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Okamoto T, Ono T, Hori M, Yang JP, Tetsuka T, Kawabe T, Sonta S (November 1998). "Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization". Cytogenet Cell Genet. 82 (1–2): 105–6. doi:10.1159/000015077. PMID 9763672.
  6. ^ "Entrez Gene: NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta".
  7. ^ Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (October 1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science. 278 (5339): 866–9. doi:10.1126/science.278.5339.866. PMID 9346485.
  8. ^ Chen Y, Wu J, Ghosh G (June 2003). "KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes". J. Biol. Chem. 278 (25): 23101–6. doi:10.1074/jbc.M301021200. PMID 12672800.
  9. ^ Suyang H, Phillips R, Douglas I, Ghosh S (October 1996). "Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B". Mol. Cell. Biol. 16 (10): 5444–9. doi:10.1128/mcb.16.10.5444. PMC 231544. PMID 8816457.
  10. ^ Na SY, Kim HJ, Lee SK, Choi HS, Na DS, Lee MO, Chung M, Moore DD, Lee JW (February 1998). "IkappaBbeta interacts with the retinoid X receptor and inhibits retinoid-dependent transactivation in lipopolysaccharide-treated cells". J. Biol. Chem. 273 (6): 3212–5. doi:10.1074/jbc.273.6.3212. PMID 9452433.

Further reading[edit]