NFKBIE

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NFKBIE
Identifiers
Aliases NFKBIE, IKBE, NFKB inhibitor epsilon
External IDs MGI: 1194908 HomoloGene: 36160 GeneCards: 4794
Genetically Related Diseases
Disease Name References
Rheumatoid Arthritis
RNA expression pattern
PBB GE NFKBIE 203927 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004556

NM_008690
NM_001304956

RefSeq (protein)

NP_004547.2

NP_001291885.1
NP_032716.2

Location (UCSC) Chr 6: 44.26 – 44.27 Mb Chr 17: 45.56 – 45.56 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.[4][5]

Function[edit]

NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins.[5]

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1).[4]

Interactions[edit]

NFKBIE has been shown to interact with NFKB2,[6] RELA,[6] NFKB1[6] and REL.[6][7][8]

References[edit]

Further reading[edit]