NFS1

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NFS1
Identifiers
Aliases NFS1, IscS, NIFS, HUSSY-08, NFS1 cysteine desulfurase
External IDs MGI: 1316706 HomoloGene: 5463 GeneCards: NFS1
RNA expression pattern
PBB GE NFS1 218455 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001198989
NM_021100
NM_181679

NM_010911

RefSeq (protein)

NP_001185918
NP_066923

NP_035041.2
NP_035041

Location (UCSC) Chr 20: 35.67 – 35.7 Mb Chr 2: 156.12 – 156.14 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cysteine desulfurase, mitochondrial is an enzyme that in humans is encoded by the NFS1 gene.[3][4][5]

Iron-sulfur clusters are required for the function of many cellular enzymes. The protein encoded by this gene supplies inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded protein belongs to the class-V family of pyridoxal phosphate-dependent aminotransferases.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Land T, Rouault TA (Jan 1999). "Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization". Mol Cell. 2 (6): 807–15. doi:10.1016/S1097-2765(00)80295-6. PMID 9885568. 
  4. ^ Biederbick A, Stehling O, Rosser R, Niggemeyer B, Nakai Y, Elsasser HP, Lill R (Jul 2006). "Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation". Mol Cell Biol. 26 (15): 5675–87. doi:10.1128/MCB.00112-06. PMC 1592756Freely accessible. PMID 16847322. 
  5. ^ a b "Entrez Gene: NFS1 NFS1 nitrogen fixation 1 homolog (S. cerevisiae)". 

Further reading[edit]