NFYA

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NFYA
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NFYA, CBF-A, CBF-B, HAP2, NF-YA, nuclear transcription factor Y subunit alpha
External IDs MGI: 97316 HomoloGene: 32114 GeneCards: 4800
RNA expression pattern
PBB GE NFYA 204107 at tn.png

PBB GE NFYA 204108 at tn.png

PBB GE NFYA 204109 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021705
NM_002505

NM_001110832
NM_010913

RefSeq (protein)

NP_002496.1
NP_068351.1

NP_035043.1

Location (UCSC) Chr 6: 41.07 – 41.1 Mb Chr 17: 48.39 – 48.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.[1][2]

Function[edit]

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.[3]

Interactions[edit]

NFYA has been shown to interact with Serum response factor[4] and ZHX1.[4][5] NFYA, NFYB and NFYC form the NFY complex and it has been shown that the NFY complex serves as a pioneer factor by promoting chromatin accessibility to facilitate other co-localizing cell type-specific transcription factors.[6]

References[edit]

  1. ^ Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (November 1991). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID 1774067. 
  2. ^ Maity SN, de Crombrugghe B (May 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends in Biochemical Sciences 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081. 
  3. ^ "Entrez Gene: NFYA nuclear transcription factor Y, alpha". 
  4. ^ a b Yamada K, Osawa H, Granner DK (October 1999). "Identification of proteins that interact with NF-YA". FEBS Letters 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. PMID 10571058. 
  5. ^ Yamada K, Printz RL, Osawa H, Granner DK (August 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochemical and Biophysical Research Communications 261 (3): 614–21. doi:10.1006/bbrc.1999.1087. PMID 10441475. 
  6. ^ Oldfield AJ, Yang P, Conway AE, Cinghu S, Freudenberg JM, Yellaboina S, Jothi R (September 2014). "Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors". Molecular Cell 55 (5): 708–22. doi:10.1016/j.molcel.2014.07.005. PMC 4157648. PMID 25132174. 

Further reading[edit]

  • Mantovani R (October 1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene 239 (1): 15–27. doi:10.1016/S0378-1119(99)00368-6. PMID 10571030. 
  • Li XY, Mantovani R, Hooft van Huijsduijnen R, Andre I, Benoist C, Mathis D (March 1992). "Evolutionary variation of the CCAAT-binding transcription factor NF-Y". Nucleic Acids Research 20 (5): 1087–91. doi:10.1093/nar/20.5.1087. PMC 312095. PMID 1549471. 
  • Li XY, Hooft van Huijsduijnen R, Mantovani R, Benoist C, Mathis D (May 1992). "Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain". The Journal of Biological Chemistry 267 (13): 8984–90. PMID 1577736. 
  • Becker DM, Fikes JD, Guarente L (March 1991). "A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast". Proceedings of the National Academy of Sciences of the United States of America 88 (5): 1968–72. doi:10.1073/pnas.88.5.1968. PMC 51147. PMID 2000400. 
  • Vuorio T, Maity SN, de Crombrugghe B (December 1990). "Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor". The Journal of Biological Chemistry 265 (36): 22480–6. PMID 2266139. 
  • Mantovani R, Li XY, Pessara U, Hooft van Huisjduijnen R, Benoist C, Mathis D (August 1994). "Dominant negative analogs of NF-YA". The Journal of Biological Chemistry 269 (32): 20340–6. PMID 8051128. 
  • Currie RA (December 1997). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y)". The Journal of Biological Chemistry 272 (49): 30880–8. doi:10.1074/jbc.272.49.30880. PMID 9388234. 
  • Currie RA (July 1998). "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development". The Journal of Biological Chemistry 273 (29): 18220–9. doi:10.1074/jbc.273.29.18220. PMID 9660784. 
  • Roder K, Wolf SS, Larkin KJ, Schweizer M (June 1999). "Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1". Gene 234 (1): 61–9. doi:10.1016/S0378-1119(99)00180-8. PMID 10393239. 
  • Yamada K, Printz RL, Osawa H, Granner DK (August 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochemical and Biophysical Research Communications 261 (3): 614–21. doi:10.1006/bbrc.1999.1087. PMID 10441475. 
  • Yamada K, Osawa H, Granner DK (October 1999). "Identification of proteins that interact with NF-YA". FEBS Letters 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. PMID 10571058. 
  • Fan W, Jin S, Tong T, Zhao H, Fan F, Antinore MJ, Rajasekaran B, Wu M, Zhan Q (March 2002). "BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs". The Journal of Biological Chemistry 277 (10): 8061–7. doi:10.1074/jbc.M110225200. PMID 11777930. 
  • Faniello MC, Chirico G, Quaresima B, Cuda G, Allevato G, Bevilacqua MA, Baudi F, Colantuoni V, Cimino F, Venuta S, Avvedimento VE, Costanzo F (April 2002). "An alternative model of H ferritin promoter transactivation by c-Jun". The Biochemical Journal 363 (Pt 1): 53–8. doi:10.1042/0264-6021:3630053. PMC 1222450. PMID 11903046. 
  • Bevilacqua MA, Faniello MC, Iovine B, Russo T, Cimino F, Costanzo F (November 2002). "Transcription factor NF-Y regulates differentiation of CaCo-2 cells". Archives of Biochemistry and Biophysics 407 (1): 39–44. doi:10.1016/S0003-9861(02)00436-8. PMID 12392713. 
  • Ge Y, Jensen TL, Matherly LH, Taub JW (December 2002). "Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1". Biochimica et Biophysica Acta 1579 (2-3): 73–80. doi:10.1016/s0167-4781(02)00509-2. PMID 12427542. 
  • Salsi V, Caretti G, Wasner M, Reinhard W, Haugwitz U, Engeland K, Mantovani R (February 2003). "Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function". The Journal of Biological Chemistry 278 (9): 6642–50. doi:10.1074/jbc.M210065200. PMID 12482752. 
  • Peng Y, Jahroudi N (March 2003). "The NFY transcription factor inhibits von Willebrand factor promoter activation in non-endothelial cells through recruitment of histone deacetylases". The Journal of Biological Chemistry 278 (10): 8385–94. doi:10.1074/jbc.M213156200. PMID 12511565. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.