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Nuclear transcription factor Y, alpha
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NFYA ; CBF-A; CBF-B; HAP2; NF-YA
External IDs OMIM189903 MGI97316 HomoloGene32114 GeneCards: NFYA Gene
RNA expression pattern
PBB GE NFYA 204109 s at tn.png
PBB GE NFYA 204107 at tn.png
PBB GE NFYA 204108 at tn.png
More reference expression data
Species Human Mouse
Entrez 4800 18044
Ensembl ENSG00000001167 ENSMUSG00000023994
UniProt P23511 P23708
RefSeq (mRNA) NM_002505 NM_001110832
RefSeq (protein) NP_002496 NP_001104302
Location (UCSC) Chr 6:
41.07 – 41.1 Mb
Chr 17:
48.39 – 48.41 Mb
PubMed search [1] [2]

Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.[1][2]


The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.[3]


NFYA has been shown to interact with Serum response factor[4] and ZHX1.[4][5]


  1. ^ Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID 1774067. 
  2. ^ Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081. 
  3. ^ "Entrez Gene: NFYA nuclear transcription factor Y, alpha". 
  4. ^ a b Yamada K, Osawa H, Granner DK (Oct 1999). "Identification of proteins that interact with NF-YA". FEBS Lett. 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. PMID 10571058. 
  5. ^ Yamada K, Printz RL, Osawa H, Granner DK (Aug 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochem. Biophys. Res. Commun. 261 (3): 614–21. doi:10.1006/bbrc.1999.1087. PMID 10441475. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.