NHC could refer to:
- Nag Hammadi Codex, or Nag Hammadi Codices (e.g. NHC II, NHC XIII)
- New Hanover County, a county in North Carolina
- New Haven County, a county in Connecticut.
- The National Humanities Center in North Carolina
- The National Hurricane Center of the United States
- The Naval Historical Center of the United States
- The National Health Council of the United States
- The National Heart Centre of Singapore
- The Natural Health Center in Portland, Oregon
- The National Housing Conference in Washington, D.C.
- The National Hockey Center in St. Cloud, Minnesota
- N-Heterocyclic Carbene, a persistent carbene, commonly used as ligand in organometallic chemistry
- Nearly a Haskell Compiler, for Acorn A5000 personal computers
- New Hampshire College, the former name of what is now called Southern New Hampshire University, a private university in Manchester, New Hampshire
- No Homers Club (NoHomers.net), a large Internet forum devoted to discussing The Simpsons
- North Hertfordshire College in north Hertfordshire, England
- Nsambya Home Care of Nsambya Hospital, Uganda
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