NHP2L1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SNU13
Protein NHP2L1 PDB 1e7k.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNU13, 15.5K, FA-1, FA1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1, NHP2L1, SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)
External IDs MGI: 893586 HomoloGene: 3672 GeneCards: SNU13
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001003796
NM_005008

NM_011482

RefSeq (protein)

NP_001003796
NP_004999

NP_035612.2
NP_035612

Location (UCSC) Chr 22: 41.67 – 41.69 Mb Chr 15: 82.04 – 82.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

NHP2-like protein 1 is a protein that in humans is encoded by the NHP2L1 gene.[3][4]

Function[edit]

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.[4]

Interactions[edit]

NHP2L1 has been shown to interact with RAD17.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Saito H, Fujiwara T, Shin S, Okui K, Nakamura Y (Jan 1997). "Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2". Cytogenetics and Cell Genetics. 72 (2-3): 191–3. doi:10.1159/000134186. PMID 8978773. 
  4. ^ a b "Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)". 
  5. ^ Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB (Dec 1999). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". The Journal of Biological Chemistry. 274 (51): 36544–9. doi:10.1074/jbc.274.51.36544. PMID 10593953. 

Further reading[edit]