NICE may refer to:
- Nassau Inter-County Express, local bus system in Nassau County, New York
- National Independent Cadres and Elites in Iraq
- National Institute for Coordinated Experiments, a fictional organisation in C.S. Lewis' novel That Hideous Strength
- National Institute for Health and Care Excellence in the UK
- Neutral Ion Coupling Explorer, a candidate Small Explorer program spacecraft
- NICE Car Company, a distributor of Mega City and other electric vehicles in London
- NICE Systems, provider of contact center, call recording, trading room, air traffic control and video recording solutions
- Noorul Islam College of Engineering, Kumarakoil, India
- NICE Corridor, also known as the Bangalore - Mysore Infrastructure Corridor
- National Information & Credit Evaluation, Korea's largest comprehensive credit information provider
- National Initiative for the Care of the Elderly
- North Idaho College of Education, a former name of Lewis–Clark State College in Lewiston, Idaho
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