Ninein

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NIN
Identifiers
AliasesNIN, SCKL7, ninein
External IDsOMIM: 608684 MGI: 105108 HomoloGene: 40632 GeneCards: NIN
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for NIN
Genomic location for NIN
Band14q22.1Start50,719,763 bp[1]
End50,831,121 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016350
NM_020921
NM_182944
NM_182945
NM_182946

NM_001081453
NM_001286079
NM_001286080
NM_008697

RefSeq (protein)

NP_057434
NP_065972
NP_891989
NP_891991

NP_001074922
NP_001273008
NP_001273009
NP_032723

Location (UCSC)Chr 14: 50.72 – 50.83 MbChr 12: 70.01 – 70.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ninein is a protein that in humans is encoded by the NIN gene.[5][6][7] Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100503 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021068 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta. 1492 (2–3): 513–6. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522.
  6. ^ Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. doi:10.1006/bbrc.2000.4050. PMID 11162463.
  7. ^ a b "Entrez Gene: NIN ninein (GSK3B interacting protein)".

Further reading[edit]