Ninein

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NIN
Identifiers
Aliases NIN, SCKL7, ninein
External IDs MGI: 105108 HomoloGene: 40632 GeneCards: NIN
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016350
NM_020921
NM_182944
NM_182945
NM_182946

NM_001081453
NM_001286079
NM_001286080
NM_008697

RefSeq (protein)

NP_057434
NP_065972
NP_891989
NP_891991

Location (UCSC) Chr 14: 50.72 – 50.83 Mb Chr 12: 70.01 – 70.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ninein is a protein that in humans is encoded by the NIN gene.[3][4][5] Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta. 1492 (2–3): 513–6. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522. 
  4. ^ Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. doi:10.1006/bbrc.2000.4050. PMID 11162463. 
  5. ^ a b "Entrez Gene: NIN ninein (GSK3B interacting protein)". 

Further reading[edit]