NISCH

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NISCH
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesNISCH, I-1, IR1, IRAS, hIRAS, nischarin
External IDsHomoloGene: 130564 GeneCards: NISCH
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for NISCH
Genomic location for NISCH
Band3p21.1Start52,455,118 bp[1]
End52,493,071 bp[1]
RNA expression pattern
PBB GE NISCH 201591 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001276293
NM_001276294
NM_007184

n/a

RefSeq (protein)

NP_001263222
NP_001263223
NP_009115

n/a

Location (UCSC)Chr 3: 52.46 – 52.49 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Nischarin is a protein that in humans is encoded by the NISCH gene.[3][4][5]

Function[edit]

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.[5]

Clinical significance[edit]

Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin.[5]

Interactions[edit]

NISCH has been shown to interact with IRS4.[3]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000010322 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ a b Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J Biol Chem. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. PMID 11912194.
  4. ^ Piletz JE, Ivanov TR, Sharp JD, Ernsberger P, Chang CH, Pickard RT, Gold G, Roth B, Zhu H, Jones JC, Baldwin J, Reis DJ (Jul 2000). "Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization". DNA Cell Biol. 19 (6): 319–29. doi:10.1089/10445490050043290. PMID 10882231.
  5. ^ a b c "Entrez Gene: NISCH nischarin".

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.