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Available structures
PDB Human UniProt search: PDBe RCSB
Aliases NISCH, I-1, IR1, IRAS, hIRAS, nischarin
External IDs HomoloGene: 130564 GeneCards: NISCH
RNA expression pattern
PBB GE NISCH 201591 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 52.46 – 52.49 Mb n/a
PubMed search [1] n/a
View/Edit Human

Nischarin is a protein that in humans is encoded by the NISCH gene.[2][3][4]


This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.[4]

Clinical significance[edit]

Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin.[4]


NISCH has been shown to interact with IRS4.[2]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ a b Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J Biol Chem. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. PMID 11912194. 
  3. ^ Piletz JE, Ivanov TR, Sharp JD, Ernsberger P, Chang CH, Pickard RT, Gold G, Roth B, Zhu H, Jones JC, Baldwin J, Reis DJ (Jul 2000). "Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization". DNA Cell Biol. 19 (6): 319–29. doi:10.1089/10445490050043290. PMID 10882231. 
  4. ^ a b c "Entrez Gene: NISCH nischarin". 

Further reading[edit]

  • Ivanov TR, Jones JC, Dontenwill M, et al. (1999). "Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera.". J. Auton. Nerv. Syst. 72 (2–3): 98–110. doi:10.1016/S0165-1838(98)00094-0. PMID 9851558. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032. 
  • El-Ayoubi R, Gutkowska J, Regunathan S, Mukaddam-Daher S (2002). "Imidazoline receptors in the heart: characterization, distribution, and regulation". J. Cardiovasc. Pharmacol. 39 (6): 875–83. doi:10.1097/00005344-200206000-00013. PMID 12021582. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241Freely accessible. PMID 12477932. 
  • Edwards L, Ernsberger P (2003). "The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase". Brain Res. 980 (1): 71–9. doi:10.1016/S0006-8993(03)02893-2. PMID 12865160. 
  • Dontenwill M, Pascal G, Piletz JE, et al. (2004). "IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells". Cell Death Differ. 10 (8): 933–5. doi:10.1038/sj.cdd.4401275. PMID 12868002. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Dontenwill M, Piletz JE, Chen M, et al. (2004). "IRAS is an anti-apoptotic protein". Ann. N. Y. Acad. Sci. 1009: 400–12. doi:10.1196/annals.1304.054. PMID 15028619. 
  • Piletz JE, Deleersnijder W, Roth BL, et al. (2004). "IRAS splice variants". Ann. N. Y. Acad. Sci. 1009: 419–26. doi:10.1196/annals.1304.056. PMID 15028621. 
  • Chen MJ, Zhu HE, Piletz JE (2004). "Intracellular effect of imidazoline receptor on alpha(2A)-noradrenergic receptor". Ann. N. Y. Acad. Sci. 1009: 427–38. doi:10.1196/annals.1304.057. PMID 15028622. 
  • Zhu H, Hayes J, Chen M, et al. (2004). "Relationship between platelet imidazoline receptor-binding peptides and candidate imidazoline-1 receptor, IRAS". Ann. N. Y. Acad. Sci. 1009: 439–46. doi:10.1196/annals.1304.058. PMID 15028623. 
  • Lim KP, Hong W (2005). "Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region". J. Biol. Chem. 279 (52): 54770–82. doi:10.1074/jbc.M411315200. PMID 15475348. 
  • Li F, Wu N, Su RB, et al. (2006). "Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein". J. Cell. Biochem. 98 (6): 1615–28. doi:10.1002/jcb.20806. PMID 16598778. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.