NKX3-2

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NKX3-2
Identifiers
AliasesNKX3-2, NK3 homeobox 2, BAPX1, NKX3.2, NKX3B, SMMD
External IDsMGI: 108015 HomoloGene: 68168 GeneCards: NKX3-2
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NKX3-2
Genomic location for NKX3-2
Band4p15.33Start13,540,830 bp[1]
End13,545,050 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001189

NM_007524

RefSeq (protein)

NP_001180

NP_031550

Location (UCSC)Chr 4: 13.54 – 13.55 MbChr 5: 41.76 – 41.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe(bap) in Drosophila and therefore also known as Bapx1 (bagpipe homeobox homolog 1) . The protein encoded by this gene is a homeo domain containing transcription factor.[5]

Function[edit]

NKX3-2 plays a role in the development of the skeleton.[6] Nkx3-2 in mice also regulates patterning in the middle ear.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109705 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049691 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Yoshiura KI, Murray JC (October 1997). "Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia". Genomics. 45 (2): 425–8. doi:10.1006/geno.1997.4926. PMID 9344671.
  6. ^ Lettice L, Hecksher-Sørensen J, Hill R (2001). "The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeleton". J. Anat. 199 (Pt 1–2): 181–7. doi:10.1111/j.1469-7580.2008.00944.x. PMC 1594973. PMID 11523821.
  7. ^ Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE (2004). "Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution". Development. 131 (6): 1235–1245. doi:10.1242/dev.01017. PMID 14973294.

External links[edit]