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NK3 homeobox 2
Symbols NKX3-2 ; BAPX1; NKX3.2; NKX3B; SMMD
External IDs OMIM602183 HomoloGene68168 GeneCards: NKX3-2 Gene
Species Human Mouse
Entrez 579 12020
Ensembl ENSG00000109705 ENSMUSG00000049691
UniProt P78367 P97503
RefSeq (mRNA) NM_001189 NM_007524
RefSeq (protein) NP_001180 NP_031550
Location (UCSC) Chr 4:
13.54 – 13.55 Mb
Chr 5:
41.76 – 41.76 Mb
PubMed search [1] [2]

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe(bap) in Drosophila and therefore also known as Bapx1 (bagpipe homeobox homolog 1) . The protein encoded by this gene is a homeo domain containing transcription factor.[1]


NKX3-2 plays a role in the development of the skeleton.[2] Nkx3-2 in mice also regulates patterning in the middle ear.[3]


  1. ^ Yoshiura KI, Murray JC (October 1997). "Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia". Genomics 45 (2): 425–8. doi:10.1006/geno.1997.4926. PMID 9344671. 
  2. ^ Lettice L, Hecksher-Sørensen J, Hill R (2001). "The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeleton". J. Anat. 199 (Pt 1–2): 181–7. doi:10.1111/j.1469-7580.2008.00944.x. PMC 1594973. PMID 11523821. 
  3. ^ Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE (2004). "Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution". Development 131 (6): 1235–1245. doi:10.1242/dev.01017. PMID 14973294. 

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