NKX6-1

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NKX6-1
Identifiers
Aliases NKX6-1, NKX6.1, NKX6A, NKX6-1, NK6 homeobox 1
External IDs MGI: 1206039 HomoloGene: 4495 GeneCards: NKX6-1
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NKX6-1
Genomic location for NKX6-1
Band 4q21.23 Start 84,491,987 bp[1]
End 84,498,450 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006168

NM_144955

RefSeq (protein)

NP_006159

NP_659204

Location (UCSC) Chr 4: 84.49 – 84.5 Mb Chr 4: 101.66 – 101.66 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.[5][6]

Function[edit]

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163623 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035187 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics. 40 (2): 367–70. PMID 9119408. doi:10.1006/geno.1996.4568. 
  6. ^ a b "Entrez Gene: NK6 homeobox 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.