NLGN1

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NLGN1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NLGN1, NL1, neuroligin 1
External IDs MGI: 2179435 HomoloGene: 56690 GeneCards: NLGN1
Genetically Related Diseases
periodontitis[1]
RNA expression pattern
PBB GE NLGN1 205893 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014932

NM_001163387
NM_138666

RefSeq (protein)

NP_055747

NP_619607.2
NP_001156859
NP_619607

Location (UCSC) Chr 3: 173.4 – 174.29 Mb Chr 3: 25.43 – 26.33 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.[4][5][6]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.[6][7]

Interactions[edit]

NLGN1 has been shown to interact with NRXN1[8][9] and DLG4.[10]

See also[edit]

References[edit]

  1. ^ "Diseases that are genetically associated with NLGN1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (April 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552. 
  5. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. 
  6. ^ a b "Entrez Gene: NLGN1 neuroligin 1". 
  7. ^ Scheiffele P, Fan J, Choih J, Fetter R, Serafini T (June 2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell. 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652. 
  8. ^ Comoletti D, Flynn R, Jennings LL, et al. (December 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". The Journal of Biological Chemistry. 278 (50): 50497–505. doi:10.1074/jbc.M306803200. PMID 14522992. 
  9. ^ Ichtchenko K, Nguyen T, Südhof TC (February 1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". The Journal of Biological Chemistry. 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240. 
  10. ^ Irie M, Hata Y, Takeuchi M, et al. (September 1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515. 

Further reading[edit]