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NLR family, pyrin domain containing 1
PDB 1pn5 EBI.jpg
Rendering of NLRP1 from PDB 1PN5
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606636 MGI2684861 HomoloGene19080 ChEMBL: 1741214 GeneCards: NLRP1 Gene
RNA expression pattern
PBB GE NLRP1 210113 s at tn.png
PBB GE NLRP1 211822 s at tn.png
PBB GE NLRP1 211824 x at tn.png
More reference expression data
Species Human Mouse
Entrez 22861 637515
Ensembl ENSG00000091592 ENSMUSG00000070390
UniProt Q9C000 Q2LKU9
RefSeq (mRNA) NM_001033053 NM_001039680
RefSeq (protein) NP_001028225 NP_001035786
Location (UCSC) Chr 17:
5.5 – 5.62 Mb
Chr 11:
71.15 – 71.23 Mb
PubMed search [1] [2]

NACHT, LRR and PYD domains-containing protein 1 is a protein that in humans is encoded by the NLRP1 gene.[1][2][3]


This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. The NLRP1 protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.[3]


NLRP1 has been shown to interact with caspase 9[4][5] and APAF1.[4]


  1. ^ Thorpe KL, Abdulla S, Kaufman J, Trowsdale J, Beck S (Oct 1996). "Phylogeny and structure of the RING3 gene". Immunogenetics 44 (5): 391–6. doi:10.1007/BF02602785. PMID 8781126. 
  2. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  3. ^ a b "Entrez Gene: NLRP1 NLR family, pyrin domain containing 1". 
  4. ^ a b Chu ZL, Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, Godzik A, Reed JC (Mar 2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis". J. Biol. Chem. 276 (12): 9239–45. doi:10.1074/jbc.M006309200. PMID 11113115. 
  5. ^ Hlaing T, Guo RF, Dilley KA, Loussia JM, Morrish TA, Shi MM, Vincenz C, Ward PA (Mar 2001). "Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins". J. Biol. Chem. 276 (12): 9230–8. doi:10.1074/jbc.M009853200. PMID 11076957. 

Further reading[edit]