NLRP2

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NLRP2
Identifiers
Aliases NLRP2, CLR19.9, NALP2, NBS1, PAN1, PYPAF2, NLR family, pyrin domain containing 2, NLR family pyrin domain containing 2
External IDs MGI: 3041206 HomoloGene: 56789 GeneCards: NLRP2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017852
NM_001174081
NM_001174082
NM_001174083

NM_177690

RefSeq (protein)

NP_001167552
NP_001167553
NP_001167554
NP_060322
NP_001334932

n/a

Location (UCSC) Chr 19: 54.95 – 55 Mb Chr 7: 5.3 – 5.35 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene.[3][4][5]

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003).[supplied by OMIM][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  4. ^ Bertin J, DiStefano PS (Mar 2001). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell Death Differ. 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363. 
  5. ^ a b "Entrez Gene: NLRP2 NLR family, pyrin domain containing 2". 

Further reading[edit]