The function of this receptor is still poorly understood, but it is thought to have roles in many disorders such as pain, drug addiction, development of tolerance to opioid drugs, and psychological disorders such as anxiety and depression. Research into the function of this receptor is an important focus of current pharmaceutical development, and selective agents such as NNC 63-0532 are essential for this work.
^Guerrini R, Carra' G, Calo' G, Trapella C, Marzola E, Rizzi D, et al. (June 2004). "Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity". The Journal of Peptide Research. 63 (6): 477–84. doi:10.1111/j.1399-3011.2004.00157.x. PMID15175020.
^Chiou LC, Liao YY, Fan PC, Kuo PH, Wang CH, Riemer C, Prinssen EP (January 2007). "Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications". Current Drug Targets. 8 (1): 117–35. doi:10.2174/138945007779315605. PMID17266536.