NNE1 (also known as NNEI, MN-24 and AM-6527) is an indole-based synthetic cannabinoid, representing a molecular hybrid of APICA and JWH-018 that is an  agonist for the cannabinoid receptors, with values of 60.09 nM at K i CB and 45.298 nM at 1 CB and 2 EC values of 9.481 nM at CB 50 1 and 1.008 nM at CB 2. It was invented by  Abbott and has a CB pEC 1 receptor 50 of 8.9 with around 80x selectivity over the related CB. 2 receptor It is suspected that metabolic hydrolysis of the amide group of NNE1 may release  1-naphthylamine, a known carcinogen, given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, and NNE1 was banned in New Zealand in 2012 as a temporary class drug to stop it being used as an ingredient in then-legal synthetic cannabis products. NNE1 was subsequently found to be responsible for the death of a man in Japan in 2014. 
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References [ edit ]
Nahoko Uchiyama; et al. (October 2014). "Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products". Forensic Science International. 243: 1–13. doi: 10.1016/j.forsciint.2014.03.013. PMID 24769262.
Gamage, Thomas F.; Farquhar, Charlotte E.; Lefever, Timothy W.; Marusich, Julie A.; Kevin, Richard C.; McGregor, Iain S.; Wiley, Jenny L.; Thomas, Brian F. (April 2018). "Molecular and behavioral pharmacological characterization of abused synthetic cannabinoids MMB- and MDMB-FUBINACA, MN-18, NNEI, CUMYL-PICA, and 5-fluoro-CUMYL-PICA". Journal of Pharmacology and Experimental Therapeutics. 365 (1): 437–446. doi: 10.1124/jpet.117.246983. ISSN 0022-3565. PMC . 5932312 PMID 29549157.
Antoni R. Blaazer; et al. (October 2011). "Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties and biological activity". European Journal of Medicinal Chemistry. 46 (10): 5086–5098. doi: 10.1016/j.ejmech.2011.08.021. PMID 21885167.
New Zealand Government Gazette, Notice Number 7051, 1 November 2012
Chizuko Sasaki; et al. (January 2015). "A case of death caused by abuse of a synthetic cannabinoid N -1-naphthalenyl-1-pentyl-1H -indole-3-carboxamide". Forensic Toxicology. 33 (1): 165–169. doi: 10.1007/s11419-014-0246-5.