NOBOX

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NOBOX
Identifiers
Aliases NOBOX, OG-2, OG2, OG2X, POF5, TCAG_12042, NOBOX oogenesis homeobox
External IDs MGI: 108011 HomoloGene: 51066 GeneCards: 135935
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080413

NM_130869

RefSeq (protein)

NP_001073882.3

NP_570939.1

Location (UCSC) Chr 7: 144.4 – 144.41 Mb Chr 6: 43.3 – 43.31 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein NOBOX, also known as newborn ovary homeobox protein, is a protein that in humans is encoded by the NOBOX gene.[1][2][3]

Function[edit]

NOBOX is a homeobox gene that is preferentially expressed in oocytes. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes.[3]

Clinical significance[edit]

A mutation in the NOBOX gene is associated with premature ovarian failure.[4]

References[edit]

  1. ^ "Entrez Gene: NOBOX oogenesis homeobox". 
  2. ^ Suzumori N, Yan C, Matzuk MM, Rajkovic A (Feb 2002). "Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes". Mechanisms of Development 111 (1-2): 137–41. doi:10.1016/S0925-4773(01)00620-7. PMID 11804785. 
  3. ^ a b Huntriss J, Hinkins M, Picton HM (May 2006). "cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles". Molecular Human Reproduction 12 (5): 283–9. doi:10.1093/molehr/gal035. PMID 16597639. 
  4. ^ Qin Y, Choi Y, Zhao H, Simpson JL, Chen ZJ, Rajkovic A (Sep 2007). "NOBOX homeobox mutation causes premature ovarian failure". American Journal of Human Genetics 81 (3): 576–81. doi:10.1086/519496. PMC 1950834. PMID 17701902. 

Further reading[edit]