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NOBOX oogenesis homeobox
Symbols NOBOX ; OG-2; OG2; OG2X; POF5; TCAG_12042
External IDs OMIM610934 MGI108011 HomoloGene51066 GeneCards: NOBOX Gene
Species Human Mouse
Entrez 135935 18291
Ensembl ENSG00000106410 ENSMUSG00000029736
UniProt O60393 Q8VIH1
RefSeq (mRNA) NM_001080413 NM_130869
RefSeq (protein) NP_001073882 NP_570939
Location (UCSC) Chr 7:
144.4 – 144.41 Mb
Chr 6:
43.3 – 43.31 Mb
PubMed search [1] [2]

Homeobox protein NOBOX, also known as newborn ovary homeobox protein, is a protein that in humans is encoded by the NOBOX gene.[1][2][3]


NOBOX is a homeobox gene that is preferentially expressed in oocytes. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes.[3]

Clinical significance[edit]

A mutation in the NOBOX gene is associated with premature ovarian failure.[4]


  1. ^ "Entrez Gene: NOBOX oogenesis homeobox". 
  2. ^ Suzumori N, Yan C, Matzuk MM, Rajkovic A (February 2002). "Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes". Mech. Dev. 111 (1-2): 137–41. doi:10.1016/S0925-4773(01)00620-7. PMID 11804785. 
  3. ^ a b Huntriss J, Hinkins M, Picton HM (May 2006). "cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles". Mol. Hum. Reprod. 12 (5): 283–9. doi:10.1093/molehr/gal035. PMID 16597639. 
  4. ^ Qin Y, Choi Y, Zhao H, Simpson JL, Chen ZJ, Rajkovic A (September 2007). "NOBOX homeobox mutation causes premature ovarian failure". Am. J. Hum. Genet. 81 (3): 576–81. doi:10.1086/519496. PMC 1950834. PMID 17701902. 

Further reading[edit]