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Nucleotide-binding oligomerization domain containing 1
Protein NOD1 PDB 2b1w.png
PDB rendering based on 2b1w.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NOD1 ; CARD4; CLR7.1; NLRC1
External IDs OMIM605980 MGI1341839 HomoloGene4440 ChEMBL: 1293222 GeneCards: NOD1 Gene
RNA expression pattern
PBB GE NOD1 221073 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10392 107607
Ensembl ENSG00000106100 ENSMUSG00000038058
UniProt Q9Y239 Q8BHB0
RefSeq (mRNA) NM_006092 NM_001171007
RefSeq (protein) NP_006083 NP_001164478
Location (UCSC) Chr 7:
30.42 – 30.48 Mb
Chr 6:
54.92 – 54.97 Mb
PubMed search [1] [2]

Nucleotide-binding oligomerization domain-containing protein 1 is a protein receptor that in humans is encoded by the NOD1 gene.[1][2] It recognizes bacterial molecules and stimulates an immune reaction.

NOD1 protein contains a caspase recruitment domain (CARD). NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing bacterial molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety. Nod1 interacts with RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor NF-κB.

Further reading[edit]


  1. ^ Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS (Jun 1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". J Biol Chem 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040. 
  2. ^ Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nunez G (Jul 1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". J Biol Chem 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646. 

External links[edit]