NOL6

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NOL6
Identifiers
Aliases NOL6, NRAP, UTP22, bA311H10.1, nucleolar protein 6
External IDs MGI: 2140151 HomoloGene: 41505 GeneCards: NOL6
RNA expression pattern
PBB GE NOL6 218199 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139235
NM_022917
NM_130793

NM_139236
NM_139237

RefSeq (protein)

NP_075068
NP_631981

NP_631982.2
NP_631982

Location (UCSC) Chr 9: 33.46 – 33.47 Mb Chr 4: 41.11 – 41.12 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.[3][4][5]

The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Utama B, Kennedy D, Ru K, Mattick JS (Mar 2002). "Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans". Genes Cells. 7 (2): 115–32. doi:10.1046/j.1356-9597.2001.00507.x. PMID 11895476. 
  4. ^ Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036Freely accessible. PMID 15590835. 
  5. ^ a b "Entrez Gene: NOL6 nucleolar protein family 6 (RNA-associated)". 

Further reading[edit]