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NADPH oxidase 4
Symbols NOX4 ; KOX; KOX-1; RENOX
External IDs OMIM605261 MGI1354184 HomoloGene41065 ChEMBL: 1250375 GeneCards: NOX4 Gene
EC number 1.6.3.-
RNA expression pattern
PBB GE NOX4 219773 at tn.png
More reference expression data
Species Human Mouse
Entrez 50507 50490
Ensembl ENSG00000086991 ENSMUSG00000030562
UniProt Q9NPH5 Q9JHI8
RefSeq (mRNA) NM_001143836 NM_001285833
RefSeq (protein) NP_001137308 NP_001272762
Location (UCSC) Chr 11:
89.32 – 89.5 Mb
Chr 7:
87.25 – 87.4 Mb
PubMed search [1] [2]

NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases.[1]


Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex.[1] Nox4 protects the vasculature against inflammatory stress.[2] Nox-dependent reactive oxygen species modulation by amino endoperoxides can induce apoptosis in high Nox4-expressing cancer cells.[3]


  1. ^ a b "Entrez Gene: NOX4 NADPH oxidase 4". 
  2. ^ Schröder K, Zhang M, Benkhoff S, Mieth A, Pliquett R, Kosowski J, Kruse C, Luedike P, Michaelis UR, Weissmann N, Dimmeler S, Shah AM, Brandes RP (April 2012). "Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase". Circ. Res. 110 (9): 1217–25. doi:10.1161/CIRCRESAHA.112.267054. PMID 22456182. 
  3. ^ Zhu P, Tong BM, Wang R, Chen JP, Foo S, Chong HC, Wang XL, Ang GY, Chiba S, Tan NS (March 2013). "Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells.". Cell Death Dis. 4: e552. doi:10.1038/cddis.2013.68. PMID 23519121. 

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