NOX4

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NOX4
Identifiers
Aliases NOX4, KOX, KOX-1, RENOX, NADPH oxidase 4
External IDs MGI: 1354184 HomoloGene: 41065 GeneCards: NOX4
Genetically Related Diseases
obesity[1]
RNA expression pattern
PBB GE NOX4 219773 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001285833
NM_001285835
NM_015760

RefSeq (protein)

NP_056575.1
NP_001272762
NP_001272764
NP_056575

Location (UCSC) Chr 11: 89.32 – 89.5 Mb Chr 7: 87.25 – 87.4 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases.[4]

Function[edit]

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex.[4] Nox4 protects the vasculature against inflammatory stress.[5] Nox-dependent reactive oxygen species modulation by amino endoperoxides can induce apoptosis in high Nox4-expressing cancer cells.[6]

References[edit]

  1. ^ "Diseases that are genetically associated with NOX4 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b "Entrez Gene: NOX4 NADPH oxidase 4". 
  5. ^ Schröder K, Zhang M, Benkhoff S, Mieth A, Pliquett R, Kosowski J, Kruse C, Luedike P, Michaelis UR, Weissmann N, Dimmeler S, Shah AM, Brandes RP (April 2012). "Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase". Circ. Res. 110 (9): 1217–25. doi:10.1161/CIRCRESAHA.112.267054. PMID 22456182. 
  6. ^ Zhu P, Tong BM, Wang R, Chen JP, Foo S, Chong HC, Wang XL, Ang GY, Chiba S, Tan NS (March 2013). "Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells.". Cell Death Dis. 4: e552. doi:10.1038/cddis.2013.68. PMID 23519121. 

Further reading[edit]