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Aliases NPAS2, MOP4, PASD4, bHLHe9, neuronal PAS domain protein 2
External IDs OMIM: 603347 MGI: 109232 HomoloGene: 1887 GeneCards: NPAS2
RNA expression pattern
PBB GE NPAS2 205459 s at fs.png

PBB GE NPAS2 39548 at fs.png

PBB GE NPAS2 205460 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 100.82 – 101 Mb Chr 1: 39.19 – 39.36 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Neuronal PAS domain-containing protein 2 is a protein that in humans is encoded by the NPAS2 gene.[3][4]


The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.[5]

NPAS2 has been shown to be analogous to the function of CLOCK in CLOCK deficient mice.[6]


NPAS2 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL (Mar 1997). "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proc Natl Acad Sci USA. 94 (2): 713–8. doi:10.1073/pnas.94.2.713. PMC 19579Freely accessible. PMID 9012850. 
  4. ^ Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA (May 1997). "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". J Biol Chem. 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689. 
  5. ^ "Entrez Gene: NPAS2 neuronal PAS domain protein 2". 
  6. ^ Debruyne JP (December 2008). "Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system". J. Genet. 87 (5): 437–46. doi:10.1007/s12041-008-0066-7. PMC 2749070Freely accessible. PMID 19147932. 
  7. ^ a b McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA (June 2001). "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock". Cell. 105 (7): 877–89. doi:10.1016/S0092-8674(01)00401-9. PMID 11439184. 
  8. ^ Hogenesch JB, Gu YZ, Jain S, Bradfield CA (May 1998). "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5474–9. doi:10.1073/pnas.95.10.5474. PMC 20401Freely accessible. PMID 9576906. 
  9. ^ Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P (February 2004). "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock". J. Biol. Chem. 279 (8): 7091–7. doi:10.1074/jbc.M311973200. PMID 14645221. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.